AFC Wimbledon have played Southport 4 times in competitive football, winning 3, drawing 1 and losing 0, first meeting on 3 Sep 1977 and most recently on 22 Jan 2011. Every meeting is listed below.
| Date | Season | Competition | Venue | Opponent | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 3 Sep 1977 | 1977–78 | Fourth Division | H | Southport | 2–2 | ||
| 17 Apr 1978 | 1977–78 | Fourth Division | A | Southport | 5–0 | ||
| 14 Aug 2010 | 2010–11 | Other | A | Southport | 1–0 | Christian Jolley 72 | 1,802 |
| 22 Jan 2011 | 2010–11 | Other | H | Southport | 5–0 | James Mulley 20, L. Moore 50, S. Moore 56, Sam Hatton 86, James Mulley 90 | 3,408 |
All AFC Wimbledon head-to-head records · AFC Wimbledon season by season