Newcastle United have played K.S.C. Lokeren Oost-Vlaanderen 2 times in competitive football, winning 2, drawing 0 and losing 0, first meeting on 14 Jul 2001 and most recently on 21 Jul 2001. Every meeting is listed below.
| Date | Season | Competition | Venue | Opponent | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 14 Jul 2001 | 2001–02 | UEFA Cup | A | K.S.C. Lokeren Oost-Vlaanderen | 4–0 | Wayne Quinn 13, Shola Ameobi 23, Shola Ameobi 39, Lomana LuaLua 85 | 6,000 |
| 21 Jul 2001 | 2001–02 | UEFA Cup | H | K.S.C. Lokeren Oost-Vlaanderen | 1–0 | Craig Bellamy 60 | 29,021 |
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