Every competitive match Reading played in 1880–81 — 2 matches, 1 won, 0 drawn, 1 lost, with scorers and attendances where the record holds them.
| Date | Competition | Venue | Opponent | Their season | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 13 Nov 1880 | FA Cup | H | Hotspur | 5–1 | |||
| 18 Dec 1880 | FA Cup | H | Swifts | 0–1 |
All 127 Reading seasons · Reading head-to-head records · Reading players