Every competitive match Sheffield Wednesday played in 1880–81 — 3 matches, 2 won, 0 drawn, 1 lost, with scorers and attendances where the record holds them.
| Date | Competition | Venue | Opponent | Their season | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 18 Dec 1880 | FA Cup | A | Blackburn Rovers | Blackburn Rovers 1880–81 | 4–0 | ||
| 8 Jan 1881 | FA Cup | A | Turton | 2–0 | |||
| 5 Feb 1881 | FA Cup | A | Darwen | 2–5 |
All 137 Sheffield Wednesday seasons · Sheffield Wednesday head-to-head records · Sheffield Wednesday players